HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-Hydroxy-5-methoxyphenyl)ethanone oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-(2-Hydroxy-5-methoxyphenyl)ethan-1-one | HCID 69714 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(2-Hydroxy-5-methoxyphenyl)ethanone oxime | HCID 5082782 | 84% |
Reaction Steps
A mixture of 2-Hydroxy-5-methoxyacetophenone (15.0 g, 0.09 mol.), potassium hydroxide (23.6 g, 0.36 mol.) and hydroxylamine hydrochloride (9.4 g, 0.14 mol.) in water (300 mL) was refluxed for 2 hrs. The mixture was poured into ice and acidified with 1N hydrochloric acid to pH 1. The resulting precipitate was filtered and dried to give 13.7 g solid. MS (m/e): 182 (M++1, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380218B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-3556c28433e547c9b5855957c3c1f6a5 |
| Source note | uspto-grants-2002_04 |