HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(1R)-1-Hydroxyethyl]benzonitrile → 4'-Cyanoacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(1R)-1-Hydroxyethyl]benzonitrile | HCID 11105510 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4'-Cyanoacetophenone | HCID 74044 | — |
Reaction Steps
Prepared in an analogous manner to that of Preparation 247 starting with (R)-(+)-4-(1-Hydroxy-ethyl)-benzonitrile which is obtained from 4-acetylbenzonitrile using 1.0 M (S)-2-Methyl-CBS-oxazaborolidine in toluene in an analogous fashion as in Preparation 248.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380218B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-d3e91073a81748c28a4855bfaa2ddc30 |
| Source note | uspto-grants-2002_04 |