Acetyl chloride → HCID 22612117, compound

Participants

Reaction Steps

A solution of N-(4-Amino-benzyl)-2-(4-fluoro-phenoxy)-nicotinamide (0.105 grams, 0.31 mmole) and triethyl amine (0.047 grams, 0.46 mmole) in methylene chloride was cooled to 0° C., and Acetyl chloride (0.029 grams, 0.37 mmole) was added. The mixture was stirred for 10 minutes and then allowed to warm to room temperature for 30 minutes. The mixture was diluted with water and extracted with methylene chloride. The combined organics were washed with brine, dried over Na2SO4, filtered and concentrated to give a solid . Recrystalization from ethyl acetate/hexane gave a white solid. (0.082 g). M.P. 128-130° C.; Anal. calcd. for C21H18N3O3F: C, 66.48; H, 4.78; N, 11.08. Found: C, 66.14; H, 4.47; N, 11.08.

Provenance & Evidence