HCID 22612145, compound → HCID 22612333, compound

Participants

Reaction Steps

To a solution of 60 mg (0.18 mmol) (E)-2-(4-Fluorophenoxy)-3-[3-(4-methoxyphenyl)-1-propenyl]-pyridine in 50 mL of ethanol was added 50 mg of 10%Pd/C, and the mixture was hydrogenated at 45 psi on a Parr Shaker Apparatus for 2 h. The catalyst was removed by filtration, and the filtrate was concentrated to afford 50 mg (83% yield) of the title compound as a colorless oil. 1H NMR (CDCl3) d 1.92-2.06 (2H, m), 2.67 (2H, t, J=8 Hz), 2.75 (2H, t, J=8 Hz), 3.80 (3H, s), 6.82-7.14 (9H, m), 7.52 (1H, dd, J=2, 7 Hz), 7.99 (1H, dd, J=2, 5 Hz); thermospray MS: m/e 338 (M++1).

Provenance & Evidence