Dimethylformamide → HCID 22612408, compound

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Reaction Steps

To a solution of 2-(1-Oxo-indan-4-ylmethoxy)-nicotinic acid (0.220 grams, 0.818 mmole), 2-(4-Aminomethyl-phenyl)-propan-2-ol (0.128 grams, 0.779 mmole), and 1-hydroxybenzotriazole hydrate (0.116 grams, 0.857 mmole) in dry dimethylformamide (30 ml) was added 1-(3-dimethylamino)-propyl)-3-ethylcarbodiimide hydrochloride (0.1795 grams, 0.935 mmole) and stirred over night. The mixture was diluted with water and extracted with ethyl acetate. The combined extracts were washed with water and brine, dried over MgSO4, filtered and concentrated to give an oil that was purified by chromatography on silica eluting with 60% ethyl acetate/hexane to give a yellow solid. (0.078 g). M.P. 145-147° C.; Anal. calcd. for C25H24N2O4: C, 72.10; H, 5.81; N, 6.73. Found: C, 71.79; H, 5.67; N, 6.61.

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