Ammonia → HCID 22612036, compound

HRID 844084Notes

Reaction equation

HRID 844084 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][C:12]3[N:20]=[CH:19][CH:18]=[CH:17][C:13]=3[C:14]([OH:16])=O)[CH:9]=2)[CH2:4][CH2:3]1.[NH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([OH:32])([CH3:31])[CH3:30])=[CH:25][CH:24]=1.N>>[OH:32][C:29]([C:26]1[CH:27]=[CH:28][C:23]([CH2:22][NH:21][C:14](=[O:16])[C:13]2[CH:17]=[CH:18][CH:19]=[N:20][C:12]=2[O:11][C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[CH2:4][CH2:3][C:2]3=[O:1])=[CH:24][CH:25]=1)([CH3:31])[CH3:30]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 101542112-[4-(Aminomethyl)phenyl]propan-2-olHCID 226123352-[(2,3-Dihydro-3-oxo-1H-inden-5-yl)oxy]-3-pyridinecarboxylic acid

Product 1

HCID 22612036HCID 22612036, compound

Procedure

Prepared from 2-(3-Oxo-indan-5-yloxy)-nicotinic acid and 2-(4-aminomethyl-phenyl)-propan-2-ol. MS (m/e): 435 (M++NH3), 417 (M++1), 400 (100). NMR (CDCl3): 8.62 (dd, J=2,8 Hz, 1H), 8.15 (dd, J=2,5 Hz, 1H), 8.07 (m, 1H), 7.32 (m, 8H), 4.67 (d, J=6 Hz, 2H), 313 (t, J=6 Hz, 2H), 2.72 (dt, J=2,4 Hz, 2H), 1.53 (s, 6H).

Sources & evidence

ORD record
ord-16358a82d28a4759ac62c7482ef07394
Source dataset
uspto-grants-2002_04
Patent number
US06380218B1

Reaction notes

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