Ammonia → HCID 22612237, compound

HRID 844087Notes

Reaction equation

HRID 844087 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][C:19]=1[Cl:20])[O:7][C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=O)(=[O:3])[CH3:2].[NH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([OH:32])([CH3:31])[CH3:30])=[CH:25][CH:24]=1.N>>[C:1]([C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][C:19]=1[Cl:20])[O:7][C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([NH:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([OH:32])([CH3:30])[CH3:31])=[CH:25][CH:24]=1)=[O:12])(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 101542112-[4-(Aminomethyl)phenyl]propan-2-olHCID 22612165HCID 22612165, compound

Product 1

HCID 22612237HCID 22612237, compound

Procedure

Prepared from 2-(3-Acetyl-4-chloro-phenoxy)-nicotinic acid and 2-(4-aminomethyl-phenyl)-propan-2-ol. MS (m/e): 456/458 (M++NH3, 100). NMR (CDCl3): 8.64 (dd, J=2,8 Hz, 1H), 8.18 (dd, J=2,5 Hz, 1H), 7.95 (m, 1H), 7.46 (m, 3H), 7.31 (m, 3H), 7.19 (m, 2H), 4.68 (d, J=6 Hz, 2H), 2.66 (s, 3H), 1.56 (s, 6H).

Sources & evidence

ORD record
ord-8055e7306e2942ddb545cde9bb80626b
Source dataset
uspto-grants-2002_04
Patent number
US06380218B1

Reaction notes

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