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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 844089Generated: October 27, 2026

2-(3-Acetyl-phenoxy)-nicotinic acid → (R)-(+)-2-(3-Acetyl-phenoxy)-N-(4-(1-hydroxy-ethyl)-benzyl)-nicotinamide

https://huagongshe.com/reaction/844089

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-Acetyl-phenoxy)-nicotinic acidHCID 12202646—
Reactant(R)-(+)-1-(4-Aminomethyl-cyclohexyl)-ethanolHCID 54376570—
SolventChloroformHCID 6212—
Product(R)-(+)-2-(3-Acetyl-phenoxy)-N-(4-(1-hydroxy-ethyl)-benzyl)-nicotinamideHCID 54493465—

Reaction Steps

Prepared from 2-(3-Acetyl-phenoxy)-nicotinic acid and (R)-(+)-1-(4-Aminomethyl-cyclohexyl)-ethanol. mp 104-6° C. αD (CHCl3) +14.0°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06380218B1
Source datasetuspto-grants-2002_04
ORD IDord-a12372191f0c4ec6b2591a40d51faac1
Source noteuspto-grants-2002_04