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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 844090Generated: October 25, 2026

2-(3-Acetyl-phenoxy)-nicotinic acid → 2-(3-Acetyl-phenoxy)-N-(2-fluoro-4-(1-hydroxy-1-methyl-ethyl)-benzyl)-nicotinamide

https://huagongshe.com/reaction/844090

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-Acetyl-phenoxy)-nicotinic acidHCID 12202646—
Reactant2-(4-Aminomethyl-3-fluoro-phenyl)-propan-2-olHCID 22481648—
Product2-(3-Acetyl-phenoxy)-N-(2-fluoro-4-(1-hydroxy-1-methyl-ethyl)-benzyl)-nicotinamideHCID 22612233—

Reaction Steps

Prepared from 2-(3-Acetyl-phenoxy)-nicotinic acid and 2-(4-Aminomethyl-3-fluoro-phenyl)-propan-2-ol. mp 68-70° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06380218B1
Source datasetuspto-grants-2002_04
ORD IDord-05a2a46beda5465d9ec15ebf1e1c2314
Source noteuspto-grants-2002_04