(3-Chlorophenyl)boronic acid → HCID 10220791, compound

HRID 844111Notes

Reaction equation

HRID 844111 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8](Br)[CH:9]=[CH:10][C:5]=2[NH:4][C:3]1=[O:12].[Cl:13][C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[CH:19]=[C:18]([C:8]2[CH:9]=[CH:10][C:5]3[NH:4][C:3](=[O:12])[N:2]([CH3:1])[C:6]=3[CH:7]=2)[CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 98159826-broMo-1-Methyl-1H-benzo[d]iMidazol-2(3H)-one

Product 1

HCID 10220791HCID 10220791, compound

Procedure

Prepared from 1-methyl-6-bromo-1,3-dihydro-benzoimidazol-2-one and 3-chloro-phenyl boronic acid in the same fashion as that of Example 5. mp 219-220° C.; 1H-NMR (DMSO-d6) δ11.0 (s, 1H), 7.75 (bs, 1H), 7.65 (dd, 1H, J=7.5, 1.76 Hz), 7.49-7.44 (m, 2H), 7.39-7.32 (m, 2H), 7.06 (d, 1H, J=7.94 Hz), 3.35 (s, 3H); MS (ES) m/z 259([M+H]+, 100%); Anal. Calc. For C14H11ClN2O: C, 65; H, 4.29; N, 10.83. Found: C, 64.44; H, 4.36; N, 10.6.

Sources & evidence

ORD record
ord-153057425602462e97d1fc75b5722d2b
Source dataset
uspto-grants-2002_04
Patent number
US06380235B1

Reaction notes

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