Sulfuric Acid → HCID 16793679, compound

HRID 844200Notes

Reaction equation

HRID 844200 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:14])[CH:11]=NO.S(=O)(=O)(O)[OH:16]>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]2[C:3]=1[NH:9][C:10](=[O:14])[C:11]2=[O:16]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 57368882N-(2-Chloro-4-fluorophenyl)-2-(hydroxyimino)-acetamide

Product 1

HCID 16793679HCID 16793679, compound

Procedure

N-(2-Chloro-4-fluorophenyl)-2-(hydroxyimino)-acetamide (5.4 g, 24.9 mmol) was added portionwise to conc. sulfuric acid (70 mL) at 70° C. The mixture was stirred for 1 h, poured onto ice-water (200 mL) and filtered. The filter-cake was dried in vacuo to give crude 7-chloro-5-fluoroindole-2,3-dione which was used immediately without further purification.

Workup

  1. additionpoured onto ice-water (200 mL)
  2. filtrationfiltered
  3. customThe filter-cake was dried in vacuo

Sources & evidence

ORD record
ord-ff0cf2eeee6f430993431d931d6c287f
Source dataset
uspto-grants-2002_04
Patent number
US06380238B1

Reaction notes

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