5,6-difluoro-2,3-dihydro-1H-indole-2,3-dione → 6-Ethylthio-5-fluoroindole-2,3-dione

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Reaction Steps

6-Ethylthio-5-fluoroindole-2,3-dione was prepared from 5,6-difluoroindole-2,3-dione using sodium thioethoxide according to the method described in the synthesis of 5-fluoro-6-methylthioindole as a brown solid (2.53 g, 19%): mp 215° C.; IR νmax (Nujol)/cm−1 3286, 2926, 2855, 1766, 1712, 1619, 1467 and 1038; NMR δH (400 MHz, DMSO-d6) 1.32 (3H, t, J 7.5 Hz), 3.13 (2H, q, J 7.5 Hz), 6.77 (1H, d, J 6.0 Hz), 7.39 (1H, d, J 8.5 Hz), 10.97 (1H, brs).

Provenance & Evidence