HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid → 2H-Isoindole-2-acetic acid, 4-amino-alpha-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid | HCID 15549838 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2H-Isoindole-2-acetic acid, 4-amino-alpha-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo- | HCID 15549839 | — |
Reaction Steps
A mixture of 2-(4-nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid (5 mmol) and 10% Pd/C (250 mg) in dimethylformamide is hydrogenated under 60 psi of hydrogen in a Parr Type Shaker to afford 2-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380239B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-99ae6b197ac642b6899a5674131adc78 |
| Source note | uspto-grants-2002_04 |