Acetic Acid → HCID 15549841, compound

Participants

Reaction Steps

A mixture of aspartic acid (10 mmol) and 4-nitrophthalic anhydride (10 mmol) in 20 mL of acetic acid is heated to reflux. The cooled reaction is then concentrated in vacuo. The residue is slurried in ethyl acetate and the resulting slurry filtered to afford the desired product. As an alternative to slurry filtering, simulated moving bed chromatography can be used to purify the desired product.

Provenance & Evidence