反应详情

A mixture of isoaspargine (10 mmol) and 3-nitrophthalic anhydride (10 mmol) in 15 ml of acetic acid is heated to reflux. The cooled reaction mixture is concentrated and the residue is purified by chromatography to afford 3-(4-nitro-1-oxoisoindolin-2-yl)-3-carbamoylpropanoic acid.

1. temperatureis heated to reflux
2. customThe cooled reaction mixture
3. concentrationis concentrated
4. customthe residue is purified by chromatography