反应详情

In a 10 mL round bottom flask equipped with a stir bar was added 10% Pd/C (˜10 mg) and ethanol (3 mL). To this stirred suspension was added a solution of the compound of Example 1, above, (0.5 g; 0.13 mmol) in ethanol (2 mL), under argon. The mixture was purged with hydrogen gas in a balloon and stirred at room temperature for 14 h. The reaction mixture was filtered through a pad of celite and the solvent removed in vacuo. The crude residue was purified by column chromatography on silica gel using chloroform:ammonia/methanol (2N) (98:2) to yield the title compound as a yellow oil (0.02 g).

1. customIn a 10 mL round bottom flask equipped with a stir bar
2. customThe mixture was purged with hydrogen gas in a balloon
3. filtrationThe reaction mixture was filtered through a pad of celite
4. customthe solvent removed in vacuo
5. customThe crude residue was purified by column chromatography on silica gel