Thiophene-3-boronic acid → HCID 53670022, compound

HRID 844243Notes

Reaction equation

HRID 844243 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][N:8]2[CH2:11][C@@H:12]2[CH2:16][CH2:15][CH2:14][N:13]2[CH3:17])=[CH:4][CH:3]=1.[S:18]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19]1>>[CH3:17][N:13]1[CH2:14][CH2:15][CH2:16][C@@H:12]1[CH2:11][N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([C:20]3[CH:21]=[CH:22][S:18][CH:19]=3)[CH:10]=2)[CH:6]=[CH:7]1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 54128961HCID 54128961, compound

Product 1

HCID 53670022HCID 53670022, compound

Procedure

(39.9 mg, 79%); from (S)-6-bromo-1-((N-methylpyrrolidin-2-yl)methyl)indole (50.0 mg, 0.17 mmol) and thiophene-3-boronic acid (43.6 mg, 0.34 mmol).

Sources & evidence

ORD record
ord-72a95c59869d42e2a8aaa6246279bc08
Source dataset
uspto-grants-2002_04
Patent number
US06380242B1

Reaction notes

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