3-Pyrroline → 1-(3-(N,N-dimethylamino)propyl)-6-(3-thienyl)-1H-indazole

HRID 844254Notes

Reaction equation

Cl[CH2:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]3[CH:18]=[CH:17][S:16][CH:15]=3)[CH:12]=2)[CH:7]=[N:6]1.[NH:19]1[CH2:23]C=C[CH2:20]1>>[CH3:20][N:19]([CH2:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]3[CH:18]=[CH:17][S:16][CH:15]=3)[CH:12]=2)[CH:7]=[N:6]1)[CH3:23]

Participants

Reactant 2

HCID 660593-Pyrroline

HCID 18007587HCID 18007587, compound

Product 1

HCID 180075481-(3-(N,N-dimethylamino)propyl)-6-(3-thienyl)-1H-indazole

Procedure

1-(3-(N-pyrrolin-3-yl)propyl)-6-(3-thienyl)-1H-indazole: (20.2 mg, 82%); from 1-(3-chloropropyl)-6-(3-thienyl)-1H-indazole (22.0 mg, 0.08 mmol) and neat 3-pyrroline (250 mg, 3.6 mmol).

Sources & evidence

ORD record: ord-b795f89ad3994b3b8cf228b6a79ea513
Source dataset: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06380242B1

Reaction notes

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