反应详情

To a solution of the ester from Step C (4.81 g, 16.1 mmol) in ethanol (10 mL)/methylene chloride (10 mL) at 0° C. was added sodium hydroxide (10 M in water, 2.09 mL, 20.9 mmol). After stirring for 16 hours, the organic solvents were evaporated in vacuo at 25° C., and the water removed by a stream of nitrogen. The crude product was acidified by the addition of hydrogen chloride (1 M in diethylether, 40 mL) and reconcentrated to provide the crude product as a white solid which was sufficiently pure for use in the next step.

1. customthe organic solvents were evaporated in vacuo at 25° C.
2. customthe water removed by a stream of nitrogen
3. additionThe crude product was acidified by the addition of hydrogen chloride (1 M in diethylether, 40 mL)