HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Sulfide → Ethyl thiazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Sulfide | HCID 402 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 3-(dimethylamino)-2-isocyanoacrylate | HCID 54355309 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl thiazole-4-carboxylate | HCID 5003096 | — |
Reaction Steps
A solution of 3-dimethylamino-2-isocyano-acrylic acid ethyl ester (1.0 g) and triethylamine (3.0 g) in tetrahydrofuran (30 mL) is treated with gaseous hydrogen sulfide until all starting material is consumed. The mixture is concentrated to an oil and purified by column chromatography using silica and 25% ethyl acetate-hexanes as the eluant. The purified material (0.61 g) is isolated as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380243B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-3ececee63622481f897b0e812586607e |
| Source note | uspto-grants-2002_04 |