1-(4-Fluorophenyl)-2-methylpropan-1-ol → 1-(4-Fluorophenyl)-2-methylpropan-1-one

HRID 844333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 844333
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1.CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:12])[CH:9]([CH3:10])[CH3:11])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 104195641-(4-Fluorophenyl)-2-methylpropan-1-olHCID 131709961Jones' reagent

Produkt 1

HCID 27828291-(4-Fluorophenyl)-2-methylpropan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of 1-(4-Fluoro-phenyl)-2-methyl-propan-1-ol (1.6 g) in acetone (10 mL) at 0° C. is added Jones reagent (20 mL) with stirring. After 10 minutes excess Jones reagent is destroyed by addition of isopropyl alcohol. Diethyl ether is added followed by anhydrous magnesium and the mixture is filtered and evaporated to give the product, a yellow oil (1.2 g).

Aufarbeitung

  1. customAfter 10 minutes excess Jones reagent is destroyed by addition of isopropyl alcohol
  2. additionDiethyl ether is added
  3. filtrationthe mixture is filtered
  4. customevaporated
  5. customto give the product

Quellen und Nachweise

ORD-Eintrag
ord-0c0229716f554c31977bb4023ce7a9b7
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06380243B1

Notizen zur Reaktion

Wird geladen…