Ammonia → HCID 10225295, compound

HRID 844343Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:39]=[CH:40][CH:41]=1)[CH2:5][NH:6][C:7]([O:9][CH2:10][C@@H:11]1[C@@H:15]([O:16]C2CCCCO2)[CH2:14][C@@H:13]([O:23]C2CCCCO2)[C@H:12]1[CH2:30]/[CH:31]=[CH:32]\[CH2:33][CH2:34][CH2:35][C:36](O)=[O:37])=[S:8].[NH3:42]>>[C:36]([CH2:35][CH2:34][CH2:33]/[CH:32]=[CH:31]\[CH2:30][C@H:12]1[C@@H:13]([OH:23])[CH2:14][C@@H:15]([OH:16])[C@@H:11]1[CH2:10][O:9][C:7](=[S:8])[NH:6][CH2:5][C:4]1[CH:39]=[CH:40][CH:41]=[C:2]([Cl:1])[CH:3]=1)(=[O:37])[NH2:42]

Participants

Reactant 2

HCID 222Ammonia

HCID 86585191HCID 86585191, compound

Product 1

HCID 10225295HCID 10225295, compound

Procedure

According to the procedures described above in Examples 17 and 18 acid 7 was converted with use of ammonia to 10 mg of the above titled compound.

Sources & evidence

ORD record: ord-b4a617f72fb1457986342afed94bc34e
Source dataset: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06380250B1

Reaction notes

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