Lithium Hydroxide → HCID 22613147, compound

Participants

Reaction Steps

In a manner similar to example AI-2-1, 4-(4-dibenzylaminophenyl)-2,4-dioxobutanoic acid ethyl ester (0.29 g, 0.7 mmol) was hydrolyzed using 0.58 ml 1N LiOH in 5 ml THF to afford 0.237 g (87%) of AIV-3-1 as an orange solid. MP=161-162° C. 1H NMR (400 MHz, CDCl3) δ4.76 (s, 4H), 6.79 (d, 2H, J=9.34 Hz), 6.99 (s, 1H), 7.20 (d, 4H, J=6.78 Hz), 7.30 (t, 2H, J=7.14 Hz), 7.35 (t, 4H, J=7.33 Hz), 7.86 (d, 2H, J=9.15 Hz).

Provenance & Evidence