Citric Acid → HCID 9861952, compound

Participants

Reaction Steps

Isomer A: Into 1 mL distilled tetrahydrofuran was placed 0.046 g (0.18 mmol) of 1-[3-(1,2,3,4-tetrahydronaphthalen-1-yl)-phenyl]-ethanone (isomer A), 0.054 g (0.37 mmol) diethyl oxalate, and 0.025 g (0.37 mmol) sodium ethoxide. After stirring for 1.5 hr, excess 10% citric acid solution was added and the THF removed in vacuo. The residue was partitioned between water and ethyl acetate and extracted. The combined organic extracts were washed with water, brine, dried over anhydrous sodium sulphate, filtered, and the solvent removed in vacuo to afford the title compound which was used without further purification.

Provenance & Evidence