反应详情

6,7-Dihydropyrido[3,2-b]thieno[2,3-d]oxepin-9-yl-(2-chlorophenyl)-2-bromoethanone from Example 37 (65.0 mg, 0.150 mmol) was suspended in formamide (2 mL, 50 mmol). The reaction was microwaved on 300 watts at 130° C. for 20 minutes. Water was added and the product was extracted with ethylacetate. The organic layer was washed with water twice and brine, dried over MgSO4, and evaporated to dryness. The crude product was purified on silica gel column, eluting with 25% of ethylacetate in hexane to give 129 (yield 10 mg, 18%). MS (ESI+) 381.1

1. customThe reaction was microwaved on 300 watts at 130° C. for 20 minutes
2. extractionthe product was extracted with ethylacetate
3. washThe organic layer was washed with water twice
4. dry with materialbrine, dried over MgSO4
5. customevaporated to dryness
6. customThe crude product was purified on silica gel column
7. washeluting with 25% of ethylacetate in hexane