4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → n-(2-Chlorophenyl)-n-methyl-8-(1h-pyrazol-4-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	HCID 2774010	—
Reactant	8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide	HCID 44242427	—
Product	n-(2-Chlorophenyl)-n-methyl-8-(1h-pyrazol-4-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide	HCID 44242299	—

Reaction Steps

Following Examples 44 and 60, 8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide 150 and pyrazole-4-boronic acid pinacol ester were reacted to give 132. MS: (ESI+) 436.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846762B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-ef3ac6be0ac34638830223ae54e192a4
Source note	uspto-grants-2014_09