Acetone → 1'(Or 2')-(isopropylidene)isonicotinohydrazide

HRID 844398Notes

Reaction equation

HRID 844398 reaction equation
[C:1]([NH:9][NH2:10])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[CH3:11][C:12]([CH3:14])=O>>[CH3:11][C:12](=[N:10][NH:9][C:1](=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1)[CH3:14]

Participants

3

Reactant 2

HCID 180AcetoneHCID 3767Isoniazid

Product 1

HCID 724871'(Or 2')-(isopropylidene)isonicotinohydrazide

Conditions

Temperature
20 °C

Procedure

A four neck flask (1 liter) equipped with a thermometer, a reflux condenser and a stirrer was charged with 68.5 g (0.5 mol) of isonicotinohydrazide and 500 ml of acetone and then heated under reflux for 24 hours. The reaction liquid was cooled down to 20° C. or lower, and then crystal was filtered off and dried under reduced pressure, whereby the intended compound (white crystal) was obtained.

Workup

  1. customA four neck flask (1 liter) equipped with a thermometer, a reflux condenser and a stirrer
  2. temperatureheated
  3. temperatureunder reflux for 24 hours
  4. customThe reaction liquid
  5. filtrationlower, and then crystal was filtered off
  6. customdried under reduced pressure, whereby the intended compound (white crystal)
  7. customwas obtained

Sources & evidence

ORD record
ord-c3f313a0529d4c6bbcb1afb3ba6737ff
Source dataset
uspto-grants-2002_04
Patent number
US06380288B1

Reaction notes

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