反应详情

A four neck flask (1 liter) equipped with a thermometer and a stirrer was charged with 60.8 g (0.4 mol) of salicylohydrazide, 49.2 g (0.6 mol) of sodium acetate and 700 ml of acetic acid. Dropwise added thereto was 67.4 g (0.48 mol) of benzoyl chloride in one hour while stirring, and stirring was continued at room temperature (20° C.) for 3 hours. After finishing the reaction, 1.5 liter of deionized water was added and crystal was filtered off. After washing sufficiently the crystal with 500 ml of methanol, it was dried under reduced pressure to obtain slightly brown crystal.

1. customA four neck flask (1 liter) equipped with a thermometer and a stirrer
2. additionDropwise added
3. customin one hour
4. stirringstirring
5. customwas continued at room temperature
6. custom(20° C.)
7. customfor 3 hours
8. additionwas added
9. filtrationcrystal was filtered off
10. washAfter washing sufficiently the crystal with 500 ml of methanol, it
11. customwas dried under reduced pressure
12. customto obtain slightly brown crystal