Benzoyl chloride → HCID 178513166, compound

Participants

Reaction Conditions

Reaction Steps

A four neck flask (2 liters) equipped with a thermometer and a stirrer was charged with 88.5 g (1.0 mol) of aminoguanidine hydrochloride, 205 g (2.5 mol) of sodium acetate and 1 liter of acetic acid and cooled down to 10° C. Dropwise added thereto was 154.5 g (1.1 mol) of benzoyl chloride while stirring, and stirring was continued at room temperature (20° C.) for 12 hours. After filtering off crystal, the mother liquid was concentrated to obtain an oily substance. This was dissolved in 1 liter of deionized water, and a 48% sodium hydroxide aqueous solution was dropwise added until the pH became 13 or higher. Crystal deposited was filtered off and washed with 200 ml of deionized water, and then the crystal was dried under reduced pressure to obtain slightly brown crystal.

Provenance & Evidence