HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 4-Cyclohexyl-1-(2,5-diethoxy-4-methylphenyl)butan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 1,4-Diethoxy-2-methylbenzene | HCID 12353563 | — |
| Reactant | 4-Cyclohexylbutanoyl chloride | HCID 13315625 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 4-Cyclohexyl-1-(2,5-diethoxy-4-methylphenyl)butan-1-one | HCID 22612556 | 75.6% |
Reaction Steps
4 g of 4-cyclohexylbutyryl chloride dissolved in 10 ml of CCl4 are added to a suspension of 2.9 g of AlCl3 in 40 ml of CCl4 at +4° C. 4.2 g of 2,5-diethoxytoluene in 20 ml of CCl4 are added dropwise. After 4 hours at +4° C., the reaction medium is poured into dilute ice-cold HCl solution. DCM is added, the phases are separated out by settling and the organic phase is then dried over MgSO4. After evaporation of the solvent, the product is purified by chromatography on silica H, eluting with toluene. 5.33 g of the expected compound are obtained: m.p.=49-50° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380230B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-c1c8274ccb214c52ac9c0e02c689be9e |
| Source note | uspto-grants-2002_04 |