反应详情

19.3 g of AlCl3 are placed in 200 ml of CCl4 at +5° C. under nitrogen and 11.36 g of acetyl chloride are added, followed by portionwise addition of 20 g of 1,4-dimethoxybenzene. After stirring for 3 hours at +5° C., the mixture is poured into dilute ice-cold HCl solution. The organic phase is separated out and dried over MgSO4 and evaporated, and the residue is then chromatographed on silica, eluting with a DCM/heptane mixture (50/50; v/v) to give 24.71 g of the expected product.

1. additionthe mixture is poured into dilute ice-cold HCl solution
2. customThe organic phase is separated out
3. dry with materialdried over MgSO4
4. customevaporated
5. customthe residue is then chromatographed on silica
6. washeluting with a DCM/heptane mixture (50/50; v/v)