Water → HCID 70162721, compound

Participants

Reaction Conditions

Reaction Steps

10 ml of 1.6M n-butyllithium in hexane are added, at −30° C., to 4.27 g of 2-(2,5-dimethylpyrrol-1-yl)-4-(2,6-dimethoxy-4-methylphenyl) thiazole and the mixture is left stirring for 30 minutes at −30° C. 4.2 g of cyclohexylethanol triflate are added at −45° C., the mixture is then warmed to 0° C., water is added, this mixture is extracted with Et2O and the extracts are dried and evaporated. The gum formed is chromatographed on silica, eluting with cyclohexane/EtOAc (1/1; v/v). 0.52 g of the expected compound is obtained in the form of a colourless gum.

Provenance & Evidence