HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-Nitroindole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 5-nitro-1H-indole-2-carboxylate | HCID 280312 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Nitroindole-2-carboxylic acid | HCID 351291 | 94.4% |
Reaction Steps
13 g of ethyl 5-nitro-2-indolecarboxylate are placed in 200 ml of EtOH and the solution is treated for 12 hours with 15 g of 30% NaOH solution. After evaporation of the solvent, the residue is acidified with concentrated HCl and then filtered to give 10.8 g of the expected compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380230B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-91066413ac5e49d4a8cec32d4e5ac528 |
| Source note | uspto-grants-2002_04 |