8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide → HCID 57900118, compound

HRID 84446Notes

Reaction equation

HRID 84446 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[S:12][C:13]([C:15]([N:17]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[Cl:25])[CH3:18])=[O:16])=[CH:14][C:10]=3[CH2:9][CH2:8][O:7][C:6]=2[CH:26]=1.C(C(N)CN(C)[C:34](=O)[OH:35])(C)(C)C.[C:39]([N:46]([CH3:50])[CH2:47][CH2:48][NH2:49])([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40]>>[Cl:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[N:17]([CH3:18])[C:15]([C:13]1[S:12][C:11]2[C:5]3[CH:4]=[CH:3][C:2]([C:34]([NH:49][CH2:48][CH2:47][N:46]([CH3:50])[C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])=[O:35])=[CH:26][C:6]=3[O:7][CH2:8][CH2:9][C:10]=2[CH:14]=1)=[O:16]

Participants

3

Reactant 2

HCID 442424278-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamideHCID 86634841N-Boc-N-methyl-ethylenediamine (tert-butyl 2-aminoethyl(methyl)carbamate)

Product 1

HCID 57900118HCID 57900118, compound

Procedure

Following the procedure of Example 13 and General Procedure C, 8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide 150 and N-Boc-N-methyl-ethylenediamine (tert-butyl 2-aminoethyl(methyl)carbamate) were reacted to give 139. MS: (ESI+) 470.2.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ecfbf87d28694deaaf687345c3f5d933
Source dataset
uspto-grants-2014_09
Patent number
US08846762B2

Reaction notes

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