反应详情

Analogously to Example 1, by reaction of 3-cyanophenylboronic acid with methyl 3-bromo-5-methylbenzoate the compound methyl 3′-cyano-5-methylbiphenyl-3-carboxylate is obtained. By bromination with NBS and reaction with 3-hydroxybenzonitrile, methyl 3′-cyano-5-(3-cyanophenoxymethyl)biphenyl-3-carboxylate is obtained. Reaction with hydroxylamine and reduction using H2/Raney Ni affords the compound methyl 3′-carbamimidoyl-5-(3-carbamimidoylphenoxymethyl)biphenyl-3-carboxylate. By hydrolysis of the ester with aqueous NaOH, 3′-carbamimidoyl-5-(3-carbamimidoylphenoxymethyl)biphenyl-3-carboxylic acid

1. customis obtained