Ethanol → HCID 86758016, compound

HRID 844687Notes

Reaction equation

HRID 844687 reaction equation
C(OC(=O)[C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]([CH:23]2[CH2:25][CH2:24]2)[CH2:18][CH2:17][C:16]3([CH3:27])[CH3:26])=[CH:7][CH:6]=1)C.[OH-:29].[Na+].[CH2:31]([OH:33])C>>[CH:23]1([N:19]2[C:20]3[C:15](=[CH:14][C:13]([C:12]4[C:5]([C:6]#[CH:7])=[C:10]([CH:9]=[CH:8][CH:11]=4)[C:31]([OH:33])=[O:29])=[CH:22][CH:21]=3)[C:16]([CH3:26])([CH3:27])[CH2:17][CH2:18]2)[CH2:24][CH2:25]1

Participants

4

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 695488784-(1-Cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl-ethynyl)-benzoic acid ethyl ester2×

Product 1

HCID 86758016HCID 86758016, compound

Procedure

Following general procedure L and using 4-(1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-6-ylethynyl)-benzoic acid ethyl ester (Compound 61, 0.05 g, 0.13 mmol), 5 mL of ethanol and 5M sodium hydroxide solution (2 mL) followed by recrystallization from hot ethyl acetate, the title compound was obtained as a solid (0.030 g, 64%).

Workup

  1. customfollowed by recrystallization from hot ethyl acetate

Sources & evidence

ORD record
ord-e51b64b504b0409db40beb6d874de247
Source dataset
uspto-grants-2002_04
Patent number
US06380256B1

Reaction notes

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