反应详情

To a stirred solution of 4,5-dihydrobenzo[b]thieno[2,3-d]oxepine (440 mg, 2.2 mmol) and acetic acid (10 ml) in dichloromethane (10 ml) at 0° C., was added N-bromosuccinimide in portions. Reaction mixture was stirred for 18 hours, allowing solution to raise to room temperature before being concentrated in-vacuo. Residue was dissolved in ethyl acetate and sat. sodium carbonate solution. Organic phase was washed with water and brine, dried (Na2SO4) and concentrated in-vacuo to give 2-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine.

1. customReaction mixture
2. concentrationbefore being concentrated in-vacuo
3. dissolutionResidue was dissolved in ethyl acetate
4. washOrganic phase was washed with water and brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated in-vacuo