HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 844743Generated: October 30, 2026
Sodium Hydroxide → {4-[4-(1-Ethoxycyclopropyl)-3-isopropyl-phenylethynyl]-phenyl]-acetic acid
https://huagongshe.com/reaction/844743
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Reactant | Methyl {4-[4-(1-ethoxycyclopropyl)-3-isopropyl-phenylethynyl]-phenyl}acetate | HCID 86585929 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | {4-[4-(1-Ethoxycyclopropyl)-3-isopropyl-phenylethynyl]-phenyl]-acetic acid | HCID 22568932 | 70% |
Reaction Steps
Using General Procedure I; a solution of methyl {4-[4-(1-ethoxycyclopropyl)-3-isopropyl-phenylethynyl]-phenyl}-acetate (Compound 100, 130.0 mg, 0.35 mmol) in ethanol (5 mL) and tetrahydrofuran (5 mL) was treated with NaOH (120.0 mg, 3.0 mmols, 3.0 mL of a 1N aqueous solution) and stirred at 50° C. for 4 h. Work-up and isolation by HPLC (Partisil 10-pac, 10% H2O/CH3CN) afforded 88.0 mg (70%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06380256B1 |
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| Source dataset | uspto-grants-2002_04 |
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| ORD ID | ord-a2c67d1a43804462ae2e2a118e0b9f7d |
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| Source note | uspto-grants-2002_04 |
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