HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1,3-Di-tert-butyl-5-ethynyl-2-methoxy-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (3,5-Di-tert-butyl-4-methoxy-phenylethynyl)-trimethyl-silane | HCID 22568920 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 1,3-Di-tert-butyl-5-ethynyl-2-methoxy-benzene | HCID 22568851 | — |
Reaction Steps
Following General Procedure E and (3,5-di-tert-butyl-4-methoxy-phenylethynyl)-trimethyl-silane (Intermediate 168, 0.28 g, 0.9 mmol), potassium carbonate (0.98 g, 7.1 mmol) and methanol (10 mL) followed by flash column chromatography over silica gel (230-400 mesh) using hexane as the eluent, the title compound was obtained (0.23 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380256B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-74401d94eddb44d2bbbff3519774659a |
| Source note | uspto-grants-2002_04 |