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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 84482Generated: October 25, 2026

1-Aminocyclopentanemethanol → N2-(2-chlorophenyl)-N8-(1-(hydroxymethyl)cyclopentyl)-N2-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2,8-dicarboxamide

https://huagongshe.com/reaction/84482

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-AminocyclopentanemethanolHCID 66307—
Reactant2-[(2-Chloro-phenyl)-methyl-carbamoyl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-8-carboxylic acid methyl esterHCID 44242363—
ProductN2-(2-chlorophenyl)-N8-(1-(hydroxymethyl)cyclopentyl)-N2-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2,8-dicarboxamideHCID 44242635—

Reaction Steps

Following Example 47 and General Procedure C, methyl 2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate 138 and 1-amino-1-cyclopentanemethanol gave 174. MS: (ESI+) 511.0

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08846762B2
Source datasetuspto-grants-2014_09
ORD IDord-de02a86f36234cb6b0e2f9b37978e425
Source noteuspto-grants-2014_09