1-(2-Methoxyethyl)cyclopentane-1-carboxylic acid → HCID 10141712, compound

HRID 844866Notes

Reaction equation

HRID 844866 reaction equation
C[O:2][C:3](=[O:26])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:25])[N:15]([CH2:23][CH3:24])[C:16](=[O:22])[N:17]([CH2:20][CH3:21])[C:18]=2[CH3:19])=[CH:9][CH:8]=1)[NH2:5].[CH3:27][O:28][CH2:29][CH2:30][C:31]1([C:36](O)=[O:37])[CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH2:20]([N:17]1[C:18]([CH3:19])=[C:13]([C:10]2[CH:11]=[CH:12][C:7]([CH2:6][C@@H:4]([C:3]([OH:2])=[O:26])[NH:5][C:36]([C:31]3([CH2:30][CH2:29][O:28][CH3:27])[CH2:35][CH2:34][CH2:33][CH2:32]3)=[O:37])=[CH:8][CH:9]=2)[C:14](=[O:25])[N:15]([CH2:23][CH3:24])[C:16]1=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 223820551-(2-Methoxyethyl)cyclopentane-1-carboxylic acidHCID 59886534HCID 59886534, compound

Product 1

HCID 10141712HCID 10141712, compound

Procedure

4-(1,3-diethyl-6-methyl-2,4-dioxo-5-pyrimidinyl)-N-[[1-(2-methoxyethyl)cyclopentyl]carbonyl]-L-phenylalanine was prepared from 4-(1, 3-diethyl-6-methyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine methyl ester and 1-(2-methoxyethyl)cyclopentane carboxylic acid using the general procedures described in example 19 and was obtained as an amorphous white solid. ES-HRMS m/e calcd for C27H37N3O6 (M+Na) 522.2575, found 522.2581.

Workup

  1. customwas obtained as an amorphous white solid

Sources & evidence

ORD record
ord-a1857924099340b784095e3a5088903d
Source dataset
uspto-grants-2002_04
Patent number
US06380387B1

Reaction notes

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