Water → 3-Methyl-6-(trifluoromethyl)uracil

To a pre-mixed solution of sodium methoxide (55 mmol, 2.97 g) and ethyl 3-amino-4,4,4-trifluorocrotonate (55 mmol, 10.0 g) in DMSO (19 mL, dried over molecular sieves) was added methyl isocyanate (55 mmol, 3.2 g) in DMSO (2.5 mL) over 15 min at 20° C. The solution was stirred for 15 min and then another portion of sodium methoxide (27.5 mmol, 1.34 g) was added. After stirring for 15 min at 20° C., methyl isocyanate (14 mmol, 0.8 g) was added at this temperature. After a further 15 min, the reaction mixture was allowed to warm to room temperature and was stirred overnight. The resulting yellow suspension was poured into water (50 mL) to obtain a light yellow solution. The neutral impurities were extracted into diethyl ether (3×50 mL). The aqueous layer was acidified with concentrated hydrochloric acid to afford a white solid. The solids were collected by filtration and were washed with water. After air drying, 6.79 g (63% yield) of 3-methyl-6-(trifluoromethyl)uracil was obtained as a white solid: mp 235-237° C. EI-HRMS m/e calcd for C6H5F3N2O2 (M+) 194.0303, found 194.0303.

1. stirringAfter stirring for 15 min at 20° C.
2. waitAfter a further 15 min
3. stirringwas stirred overnight
4. customto obtain a light yellow solution
5. extractionThe neutral impurities were extracted into diethyl ether (3×50 mL)
6. customto afford a white solid
7. filtrationThe solids were collected by filtration
8. washwere washed with water
9. customAfter air drying

ORD record

ord-33bbf74ea65549f386d7f5ea1f57feb0

Source dataset

uspto-grants-2002_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06380387B1