反应详情

A mixture of N-(benzyloxycarbonyl)-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-3-methyl-L-phenylalanine methyl ester (0.145 mmol, 70 mg), cyclohexene (1 mL) and 10% palladium on carbon (100 mg) in ethanol (2 mL) was heated to reflux for 15 h. Then, it was filtered through a pad of celite and the pad was washed with ethanol (10 mL). The combined filtrate was concentrated under reduced pressure. The residue was dried under high vacuum to afford 36 mg (72% yield) of 4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-3-methyl-L-phenylalanine methyl ester as a light yellow solid. ES-HRMS m/e calcd for C18H23N3O4 (M+Na) 368.1327, found 368.1321.

1. temperaturewas heated
2. temperatureto reflux for 15 h
3. filtrationThen, it was filtered through a pad of celite
4. washthe pad was washed with ethanol (10 mL)
5. concentrationThe combined filtrate was concentrated under reduced pressure
6. customThe residue was dried under high vacuum