Chloroacetyl chloride → HCID 20133042, compound

HRID 844944Notes

Reaction equation

HRID 844944 reaction equation
[CH3:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][NH:3]1.[Cl:12][CH2:13][C:14](Cl)=[O:15]>C1(C)C=CC=CC=1>[Cl:12][CH2:13][C:14]([N:3]1[CH2:4][CH2:5][C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:2]1[CH3:1])=[O:15]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 922141-Methyl-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 20133042HCID 20133042, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A reaction vessel was charged with 50 ml toluene and 2 g 1-methyl-1,2,3,4-tetrahydroisoquinoline (prepared by procedure of Example 1,--Method A). Then, 2 ml 2-chloroacetyl chloride was added gradually to the mixture. The reaction mixture was stirred and heated until a homogeneous solution appeared. The mixture was filtered, stripped of solvent, and subjected to Kugelrohr distillation 130° C. @ 0.2 mm Hg) to provide 2.7 g of an amber oil product having the elemental analysis reported in Table I.

Workup

  1. temperatureheated until a homogeneous solution
  2. filtrationThe mixture was filtered
  3. distillationsubjected to Kugelrohr distillation 130° C. @ 0.2 mm Hg)

Sources & evidence

ORD record
ord-e3bb0574e34d4209a1ecbc39c2a16bb1
Source dataset
uspto-grants-1988_07
Patent number
US04755218

Reaction notes

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