1-Methyl-1,2,3,4-tetrahydroisoquinoline → HCID 20133047, compound

Participants

Reaction Steps

A reaction vessel was charged with 50 ml toluene and 2.0 g 1-methyl-1,2,3,4-tetrahydroisoquinoline (prepared by procedure of Example 1--Procedure A). Then, 2.0 ml 2-chloropropionyl chloride was added gradually to the mixture. The reaction mixture was stirred and heated until a homogeneous solution appeared. The mixture was filtered, stripped of solvent, and subjected to Kugelrohr distillation (150° C. @ 0.25 mm Hg) to provide 2.8 g of a yellow oil product having the elemental analysis reported in Table I.

Provenance & Evidence