反应详情

A reaction vessel was chrged with 2 g 1-methyl-1,2,3,4-tetrahydroisoquinoline, 10 ml 10% sodium hydroxide and 50 ml methylene chloride. With this mixture stirred, 3 ml 2,2-dichloropropionyl chloride was added dropwise to the mixture. The mixture was stirred for 20 minutes, then water was added. The organic extract was dried with magnesium sulfate, stripped of solvent and subjected to Kugelrohr distillation (170° C. @ 0.25 mm Hg) to provide 2.7 g of a yellow oil product having the elemental analysis reported in Table I.

1. stirringThe mixture was stirred for 20 minutes
2. extractionThe organic extract
3. dry with materialwas dried with magnesium sulfate
4. distillationsubjected to Kugelrohr distillation (170° C. @ 0.25 mm Hg)