Phenethylamine → HCID 20133037, compound

Participants

Reaction Steps

By procedures described in Example 1 (Method A), phenethylamine and trifluoroacetyl chloride were converted to 1-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline. A reaction vessel was charged with 3.5 g of this isoquinoline compound, 20 ml 10% sodium hydroxide and 50 ml methylene chloride. With this mixture stirred, 2 ml dichloroacetyl chloride was added dropwise to the mixture. The mixture was stirred for 2 minutes, then water was added. The organic extract was dried with magnesium sulfate, stripped of solvent, and subjected to Kugelrohr distillation (130° C. @ 0.1 mm Hg) to provide a product having the elemental analysis reported in Table I.

Provenance & Evidence