Dichloroacetyl chloride → HCID 20133039, compound

Participants

Reaction Steps

By procedures described in Example 1 (Method A), 4-methyl-phenethylamine and propionyl chloride were converted to 1-ethyl-7-methyl-1,2,3,4-tetrahydroisoquinoline. A reaction vessel was charged with 3.0 g of this isoquinoline compound, 10 ml 10% sodium hydroxide and 50 ml methylene chloride. With this mixture stirred, 2 ml dichloroacetyl chloride was added dropwise to the mixture. The mixture was stirred for 5 minutes and then made alkaline with aqueous sodium hydroxide. The organic extract was dried with magnesium sulfate, stripped of solvent and subjected to Kugelrohr distillation (105° C. @ 0.1 mm Hg) to provide 4.8 g of a yellow oil product having the elemental analysis reported in Table I.

Provenance & Evidence