2-Benzylthio-6,7-dichloro-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine → 2-Benzylthio-6-chloro-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine

HRID 844966Notes

Reaction equation

HRID 844966 reaction equation
[CH2:1]([S:8][C:9]1[N:20]=[C:12]2[N:13]=[C:14]([CH3:19])[C:15]([Cl:18])=[C:16](Cl)[N:11]2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Cu].[Zn]>[CH2:1]([S:8][C:9]1[N:20]=[C:12]2[N:13]=[C:14]([CH3:19])[C:15]([Cl:18])=[CH:16][N:11]2[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 107822752-Benzylthio-6,7-dichloro-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine

Product 1

HCID 104937602-Benzylthio-6-chloro-5-methyl-1,2,4-triazolo[1,5-a]pyrimidineYield 88%

Reagents, catalysts & solvents 1

HCID 10290809Zinc copper coupleCatalyst

Procedure

This material was prepared by reduction of 2-benzylthio-6,7-dichloro-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine with zinc-copper couple following the general procedure described in Example 21. The desired product was isolated in 88% yield as a solid, m.p. 160°-161° C. IR and 1H NMR spectra were in agreement with the assigned structure.

Sources & evidence

ORD record
ord-33abb46c7da347ada23de3c1e605a727
Source dataset
uspto-grants-1988_07
Patent number
US04755212

Reaction notes

Loading…