Acetyl chloride → 2-Acetoxymethyl-6-chloroaniline

HRID 844994Notes

Reaction equation

[NH2:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[C:11](Cl)(=[O:13])[CH3:12]>>[C:11]([O:5][CH2:4][C:3]1[CH:6]=[CH:7][CH:8]=[C:9]([Cl:10])[C:2]=1[NH2:1])(=[O:13])[CH3:12]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 14155407(2-Amino-3-chlorophenyl)methanol

Product 1

HCID 141554092-Acetoxymethyl-6-chloroaniline

Procedure

This material was prepared from 2-amino-3-chlorobenzyl alcohol and acetyl chloride by the general procedure outlined in Example 82. The product was isolated as an amber oil and was characterized by IR and 1H NMR spectroscopy and combustion analysis.

Workup

customThe product was isolated as an amber oil

Sources & evidence

ORD record: ord-204c812c907348f68d41aac254edfc43
Source dataset: uspto-grants-1988_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04755212

Reaction notes

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